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M9480025.TXT
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1994-08-09
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Document 0025
DOCN M9480025
TI [Immunologic parameters in women with normal pregnancy and
pre-eclampsia]
DT 9410
AU Bettin S; Halle H; Wenzkowski BM; Volk HD; Jahn S; Frauenklinik der
Charite, Universitatsklinikum Berlin.
SO Zentralbl Gynakol. 1994;116(5):260-2. Unique Identifier : AIDSLINE
MED/94295322
AB Immunological investigations were carried in women with normal pregnancy
and patients with preeclampsia. Regarding the lymphocyte subpopulation
distribution an elevated number of T lymphocytes, especially of CD-4
carrying helper-inducer T cells, was registered resulting in an altered
CD4/CD8 ratio. The T lymphocytes in patients with pre-eclampsia seem to
be activated in vivo, shown by an elevated expression of the CD25 (IL-2
receptor) marker. Their responsibility to phytohemagglutinin (PHA) in
vitro was found to be depressed. Furthermore, a pre-stimulation of
macrophages in vivo was registered (expression of the transferrin
receptor). In comparison to the control group the serum levels of IgG
and IgA were seen to be low in patients with pre-eclampsia.
DE Adult Antigens, CD/BLOOD CD4-CD8 Ratio English Abstract Female
Human Immune Tolerance/IMMUNOLOGY Immunoglobulins/*IMMUNOLOGY
Leukocyte Count Lymphocyte Transformation/IMMUNOLOGY
Monocytes/*IMMUNOLOGY Pre-Eclampsia/*IMMUNOLOGY Pregnancy Reference
Values T-Lymphocyte Subsets/*IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).